Presentation Title

Isolation of germicidal agents in Artemisia californica

Presentation Type

Poster

Keywords

Chemistry

Department

Chemistry

Major

Physics

Abstract

Artemisia californica is a low shrub that is native to Southern California. Our hypothesis was that this plant may contain bioactive chemical compounds based on historical accounts of its medicinal use by the Chumash Native Americans. In this project, three compounds from the plant were isolated using liquid chromatography for purification of these compounds and 1H NMR for characterization. The antibacterial bioactivity of these three compounds was assayed by measuring the optical density at 595 nm of bacterial cell cultures treated with varying concentrations of each compound. Of the three compounds isolated from A. californica, two were shown to have some form of antibacterial bioactivity against E. coli either by FabI enzyme inhibition or other means after a certain critical concentration.

Faculty Mentor

Dr. P. Matthew Joyner

Funding Source or Research Program

Undergraduate Research Fellowship

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Isolation of germicidal agents in Artemisia californica

Artemisia californica is a low shrub that is native to Southern California. Our hypothesis was that this plant may contain bioactive chemical compounds based on historical accounts of its medicinal use by the Chumash Native Americans. In this project, three compounds from the plant were isolated using liquid chromatography for purification of these compounds and 1H NMR for characterization. The antibacterial bioactivity of these three compounds was assayed by measuring the optical density at 595 nm of bacterial cell cultures treated with varying concentrations of each compound. Of the three compounds isolated from A. californica, two were shown to have some form of antibacterial bioactivity against E. coli either by FabI enzyme inhibition or other means after a certain critical concentration.